Cis/trans Isomerization of Non-prolyl Peptide Bond Observed in Crystal Structure of an Scorpion Toxin

Summary for 1KV0

Related1SN1 1SN4 1CHZ 1DJT
DescriptorAlpha-like toxin BmK-M7 (2 entities in total)
Functional Keywordsnon-prolyl cis peptide bond, cis/trans isomerization, dimeric structure, scorpion toxin, toxin
Biological sourceMesobuthus martensii (Chinese scorpion)
Cellular locationSecreted P59854
Total number of polymer chains2
Total molecular weight14504.7
Guan, R.J.,He, X.L.,Wang, M.,Xiang, Y.,Wang, D.C. (deposition date: 2002-01-23, release date: 2003-09-16, Last modification date: 2011-07-13)
Primary citation
Guan, R.J.,Xiang, Y.,He, X.L.,Wang, C.G.,Wang, M.,Zhang, Y.,Sundberg, E.J.,Wang, D.C.
Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins.
J.Mol.Biol., 341:1189-1204, 2004
PubMed: 15321715 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2004.06.067
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.173131.6%8.3%8.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1kv0
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Molmil generated image of 1kv0
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Molmil generated image of 1kv0
rotated about y axis by 90°