1KNJ

Co-Crystal Structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate Synthase (ispF) from E. coli Involved in Mevalonate-Independent Isoprenoid Biosynthesis, Complexed with CMP/MECDP/Mn2+

1KNJ の概要

• エントリーDOI: 10.2210/pdb1knj/pdb
• 関連するPDBエントリー: 1KNK
• 分子名称: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION, CYTIDINE-5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: isoprenoids, deoxyxylulose/methyl-erythritol-phosphate pathway, cyclodiphosphate, mep, ygbb, ispf, mecdp, 2-c-methyl-d-erythritol-2, 4-cyclodiphosphate synthase, metal binding protein
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17764.34

構造登録者

Richard, S.B.,Ferrer, J.L.,Bowman, M.E.,Lillo, A.M.,Tetzlaff, C.N.,Cane, D.E.,Noel, J.P. (登録日: 2001-12-18, 公開日: 2002-06-18, 最終更新日: 2011-07-13)

• 主引用文献: Richard, S.B.,Ferrer, J.L.,Bowman, M.E.,Lillo, A.M.,Tetzlaff, C.N.,Cane, D.E.,Noel, J.P.; Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.; J.Biol.Chem., 277:8667-8672, 2002; PubMed: 11786530; DOI: 10.1074/jbc.C100739200

実験手法

X-RAY DIFFRACTION (2.8 Å)