1KMZ

MOLECULAR BASIS OF MITOMYCIN C RESICTANCE IN STREPTOMYCES: CRYSTAL STRUCTURES OF THE MRD PROTEIN WITH AND WITHOUT A DRUG DERIVATIVE

Summary for 1KMZ

• Entry DOI: 10.2210/pdb1kmz/pdb
• Related: 1KLL
• Descriptor: mitomycin-binding protein (2 entities in total)
• Functional Keywords: mitomycin c, antibiotic resistance, sad, anomalous diffraction, domain swapping, p-staking, antimicrobial protein
• Biological source: Streptomyces lavendulae
• Total number of polymer chains: 1
• Total formula weight: 14395.13

Authors

Martin, T.W.,Dauter, Z.,Devedjiev, Y.,Sheffield, P.,Jelen, F.,He, M.,Sherman, D.,Otlewski, J.,Derewenda, Z.S.,Derewenda, U. (deposition date: 2001-12-17, release date: 2002-07-19, Last modification date: 2023-08-16)

• Primary citation: Martin, T.W.,Dauter, Z.,Devedjiev, Y.,Sheffield, P.,Jelen, F.,He, M.,Sherman, D.H.,Otlewski, J.,Derewenda, Z.S.,Derewenda, U.; Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.; Structure, 10:933-942, 2002; PubMed: 12121648; DOI: 10.1016/S0969-2126(02)00778-5

Experimental method

X-RAY DIFFRACTION (1.5 Å)