1KIK

SH3 Domain of Lymphocyte Specific Kinase (LCK)

1KIK の概要

• エントリーDOI: 10.2210/pdb1kik/pdb
• 関連するPDBエントリー: 1H92 1LCJ 1LCK 1QPC
• 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (1 entity in total)
• 機能のキーワード: sh3 domain, tyrosine kinase, signal transduction, lck, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P06239
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6411.06

構造登録者

Briese, L.,Willbold, D. (登録日: 2001-12-03, 公開日: 2001-12-12, 最終更新日: 2024-05-22)

主引用文献

Briese, L.,Willbold, D.
Structure determination of human Lck unique and SH3 domains by nuclear magnetic resonance spectroscopy.
Bmc Struct.Biol., 3:3-3, 2003

PubMed Abstract: Protein tyrosine kinases are involved in signal transduction pathways that regulate cell growth, differentiation, activation and transformation. Human lymphocyte specific kinase (Lck) is a 56 kDa protein involved in T-cell- and IL2-receptor signaling. Three-dimensional structures are known for SH3, SH2 and kinase domains of Lck as well as for other tyrosine kinases. No structure is known for the unique domain of any Src-type tyrosine kinase.

PubMed: 12734017
DOI: 10.1186/1472-6807-3-3

実験手法

SOLUTION NMR