1KIK
SH3 Domain of Lymphocyte Specific Kinase (LCK)
Summary for 1KIK
| Entry DOI | 10.2210/pdb1kik/pdb |
| Related | 1H92 1LCJ 1LCK 1QPC |
| Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (1 entity in total) |
| Functional Keywords | sh3 domain, tyrosine kinase, signal transduction, lck, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P06239 |
| Total number of polymer chains | 1 |
| Total formula weight | 6411.06 |
| Authors | Briese, L.,Willbold, D. (deposition date: 2001-12-03, release date: 2001-12-12, Last modification date: 2024-05-22) |
| Primary citation | Briese, L.,Willbold, D. Structure determination of human Lck unique and SH3 domains by nuclear magnetic resonance spectroscopy. Bmc Struct.Biol., 3:3-3, 2003 Cited by PubMed Abstract: Protein tyrosine kinases are involved in signal transduction pathways that regulate cell growth, differentiation, activation and transformation. Human lymphocyte specific kinase (Lck) is a 56 kDa protein involved in T-cell- and IL2-receptor signaling. Three-dimensional structures are known for SH3, SH2 and kinase domains of Lck as well as for other tyrosine kinases. No structure is known for the unique domain of any Src-type tyrosine kinase. PubMed: 12734017DOI: 10.1186/1472-6807-3-3 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
