1KF9

PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR

Summary for 1KF9

• Entry DOI: 10.2210/pdb1kf9/pdb
• Descriptor: PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238) (3 entities in total)
• Functional Keywords: cytokine, hormone-receptor complex, phage display molecular plasticity, receptor homodimerization, human growth hormone, hormone-growth factor complex, hormone/growth factor
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912
• Total number of polymer chains: 6
• Total formula weight: 153612.34

Authors

Schiffer, C.A.,Ultsch, M.,Walsh, S.,Somers, W.,De Vos, A.M.,Kossiakoff, A.A. (deposition date: 2001-11-19, release date: 2002-11-20, Last modification date: 2011-07-13)

• Primary citation: Schiffer, C.A.,Ultsch, M.,Walsh, S.,Somers, W.,De Vos, A.M.,Kossiakoff, A.A.; Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites; J.Mol.Biol., 316:277-289, 2002; PubMed: 11851338; DOI: 10.1006/jmbi.2001.5348

Experimental method

X-RAY DIFFRACTION (2.6 Å)