1KF9
PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Summary for 1KF9
Entry DOI | 10.2210/pdb1kf9/pdb |
Descriptor | PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238) (3 entities in total) |
Functional Keywords | cytokine, hormone-receptor complex, phage display molecular plasticity, receptor homodimerization, human growth hormone, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912 |
Total number of polymer chains | 6 |
Total formula weight | 153612.34 |
Authors | Schiffer, C.A.,Ultsch, M.,Walsh, S.,Somers, W.,De Vos, A.M.,Kossiakoff, A.A. (deposition date: 2001-11-19, release date: 2002-11-20, Last modification date: 2011-07-13) |
Primary citation | Schiffer, C.A.,Ultsch, M.,Walsh, S.,Somers, W.,De Vos, A.M.,Kossiakoff, A.A. Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites J.Mol.Biol., 316:277-289, 2002 Cited by PubMed: 11851338DOI: 10.1006/jmbi.2001.5348 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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