1KF9
PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
1KF9 の概要
エントリーDOI | 10.2210/pdb1kf9/pdb |
分子名称 | PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238) (3 entities in total) |
機能のキーワード | cytokine, hormone-receptor complex, phage display molecular plasticity, receptor homodimerization, human growth hormone, hormone-growth factor complex, hormone/growth factor |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 153612.34 |
構造登録者 | Schiffer, C.A.,Ultsch, M.,Walsh, S.,Somers, W.,De Vos, A.M.,Kossiakoff, A.A. (登録日: 2001-11-19, 公開日: 2002-11-20, 最終更新日: 2011-07-13) |
主引用文献 | Schiffer, C.A.,Ultsch, M.,Walsh, S.,Somers, W.,De Vos, A.M.,Kossiakoff, A.A. Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites J.Mol.Biol., 316:277-289, 2002 Cited by PubMed: 11851338DOI: 10.1006/jmbi.2001.5348 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
構造検証レポート
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