1K6T

LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE

1K6T の概要

• エントリーDOI: 10.2210/pdb1k6t/pdb
• 関連するPDBエントリー: 1K6C 1K6P 1K6V
• 分子名称: POL polyprotein, ACETATE ION, N-[2-HYDROXY-1-INDANYL]-5-[(2-TERTIARYBUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4-HYDROXY-2-(1-PHENYLETHYL)-PEN TANAMIDE, ... (4 entities in total)
• 機能のキーワード: indinavir, inhibitor recognition, hiv-1 protease, drug resistance, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P35963
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22527.49

構造登録者

Schiffer, C.A. (登録日: 2001-10-17, 公開日: 2002-02-06, 最終更新日: 2023-08-16)

• 主引用文献: King, N.M.,Melnick, L.,Prabu-Jeyabalan, M.,Nalivaika, E.A.,Yang, S.S.,Gao, Y.,Nie, X.,Zepp, C.,Heefner, D.L.,Schiffer, C.A.; Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.; Protein Sci., 11:418-429, 2002; PubMed: 11790852; DOI: 10.1110/ps.2520102

実験手法

X-RAY DIFFRACTION (2.25 Å)