1K6P

LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE

Summary for 1K6P

• Entry DOI: 10.2210/pdb1k6p/pdb
• Related: 1K6C 1K6T 1K6V
• Descriptor: POL polyprotein, ACETATE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, ... (4 entities in total)
• Functional Keywords: indinavir, inhibitor recognition, drug resistance, hiv-1 protease, hydrolase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P35963
• Total number of polymer chains: 2
• Total formula weight: 22851.71

Authors

Schiffer, C.A. (deposition date: 2001-10-16, release date: 2002-02-06, Last modification date: 2024-04-03)

• Primary citation: King, N.M.,Melnick, L.,Prabu-Jeyabalan, M.,Nalivaika, E.A.,Yang, S.S.,Gao, Y.,Nie, X.,Zepp, C.,Heefner, D.L.,Schiffer, C.A.; Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.; Protein Sci., 11:418-429, 2002; PubMed: 11790852; DOI: 10.1110/ps.2520102

Experimental method

X-RAY DIFFRACTION (2.2 Å)