1K6P
LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | POL polyprotein | polymer | 99 | 10831.8 | 2 | UniProt (P35963) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
2 | A, B | ACETATE ION | non-polymer | 59.0 | 9 | Chemie (ACT) | |||
3 | B | N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE | non-polymer | 656.8 | 1 | Chemie (XN3) | |||
4 | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P35963)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 63 | engineered mutation |
Arg 14 | Lys 70 | engineered mutation |
Thr 82 | Val 138 | engineered mutation |
Val 84 | Ile 140 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21663.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1188.2 | |
All* | Total formula weight | 22851.7 |