1K6P
LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE
Summary for 1K6P
Entry DOI | 10.2210/pdb1k6p/pdb |
Related | 1K6C 1K6T 1K6V |
Descriptor | POL polyprotein, ACETATE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, ... (4 entities in total) |
Functional Keywords | indinavir, inhibitor recognition, drug resistance, hiv-1 protease, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P35963 |
Total number of polymer chains | 2 |
Total formula weight | 22851.71 |
Authors | Schiffer, C.A. (deposition date: 2001-10-16, release date: 2002-02-06, Last modification date: 2024-04-03) |
Primary citation | King, N.M.,Melnick, L.,Prabu-Jeyabalan, M.,Nalivaika, E.A.,Yang, S.S.,Gao, Y.,Nie, X.,Zepp, C.,Heefner, D.L.,Schiffer, C.A. Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease. Protein Sci., 11:418-429, 2002 Cited by PubMed: 11790852DOI: 10.1110/ps.2520102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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