1K4Y

Crystal Structure of Rabbit Liver Carboxylesterase in Complex with 4-piperidino-piperidine

1K4Y の概要

• エントリーDOI: 10.2210/pdb1k4y/pdb
• 分子名称: LIVER CARBOXYLESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: hydrolase, esterase, side door, camptothecin, irinotecan
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60529.10

構造登録者

Bencharit, S.,Morton, C.L.,Howard-Williams, E.L.,Danks, M.K.,Potter, P.M.,Redinbo, M.R. (登録日: 2001-10-09, 公開日: 2002-05-01, 最終更新日: 2020-07-29)

• 主引用文献: Bencharit, S.,Morton, C.L.,Howard-Williams, E.L.,Danks, M.K.,Potter, P.M.,Redinbo, M.R.; Structural insights into CPT-11 activation by mammalian carboxylesterases.; Nat.Struct.Biol., 9:337-342, 2002; PubMed: 11967565; DOI: 10.1038/nsb790

実験手法

X-RAY DIFFRACTION (2.5 Å)