1K4S
HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Summary for 1K4S
Entry DOI | 10.2210/pdb1k4s/pdb |
Related | 1A31 1A35 1A36 |
Descriptor | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*(5IU)P*(5IU))-3', 5'-D(*(SPT)P*GP*AP*AP*AP*AP*AP*(5IU)P*(5IU)P*(5IU)P*(5IU)P*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*CP*AP*AP*AP*GP*(IDO)UP*CP*(IDO)UP*(IDO)UP*(IDO)UP*(IDO)UP*T)-3', ... (4 entities in total) |
Functional Keywords | complex (isomerase-dna), dna, topoisomerase i, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleolus: P11387 |
Total number of polymer chains | 4 |
Total formula weight | 85393.02 |
Authors | Staker, B.L.,Hjerrild, K.,Feese, M.D.,Behnke, C.A.,Burgin Jr., A.B.,Stewart, L.J. (deposition date: 2001-10-08, release date: 2002-12-04, Last modification date: 2023-11-15) |
Primary citation | Staker, B.L.,Hjerrild, K.,Feese, M.D.,Behnke, C.A.,Burgin Jr., A.B.,Stewart, L.J. The mechanism of topoisomerase I poisoning by a camptothecin analog Proc.Natl.Acad.Sci.USA, 99:15387-15392, 2002 Cited by PubMed: 12426403DOI: 10.1073/pnas.242259599 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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