1K27
Crystal Structure of 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with a Transition State Analogue
Summary for 1K27
Entry DOI | 10.2210/pdb1k27/pdb |
Descriptor | 5'-Deoxy-5'-Methylthioadenosine Phosphorylase, PHOSPHATE ION, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL, ... (4 entities in total) |
Functional Keywords | mtap, methylthioadenosine phosphorylase, transition state analogue, phosphate, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13126 |
Total number of polymer chains | 1 |
Total formula weight | 31669.40 |
Authors | Shi, W.,Singh, V.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. (deposition date: 2001-09-26, release date: 2003-09-30, Last modification date: 2023-08-16) |
Primary citation | Singh, V.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A Biochemistry, 43:9-18, 2004 Cited by PubMed: 14705926PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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