1K27

Crystal Structure of 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with a Transition State Analogue

1K27 の概要

• エントリーDOI: 10.2210/pdb1k27/pdb
• 分子名称: 5'-Deoxy-5'-Methylthioadenosine Phosphorylase, PHOSPHATE ION, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL, ... (4 entities in total)
• 機能のキーワード: mtap, methylthioadenosine phosphorylase, transition state analogue, phosphate, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13126
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31669.40

構造登録者

Shi, W.,Singh, V.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. (登録日: 2001-09-26, 公開日: 2003-09-30, 最終更新日: 2023-08-16)

• 主引用文献: Singh, V.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L.; Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A; Biochemistry, 43:9-18, 2004; PubMed: 14705926

実験手法

X-RAY DIFFRACTION (1.95 Å)