1K12

Fucose Binding lectin

Summary for 1K12

• Entry DOI: 10.2210/pdb1k12/pdb
• Descriptor: LECTIN, alpha-L-fucopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: beta barrel, protein carbohydrate complex, sugar binding protein
• Biological source: Anguilla anguilla (European eel)
• Cellular location: Secreted (By similarity): Q7SIC1
• Total number of polymer chains: 1
• Total formula weight: 17148.33

Authors

Bianchet, M.A.,Odom, E.W.,Vasta, G.R.,Amzel, L.M. (deposition date: 2001-09-23, release date: 2002-07-31, Last modification date: 2024-11-13)

Primary citation

Bianchet, M.A.,Odom, E.W.,Vasta, G.R.,Amzel, L.M.
A novel fucose recognition fold involved in innate immunity.
Nat.Struct.Biol., 9:628-634, 2002

PubMed Abstract: Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with alpha-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition.

PubMed: 12091873

Experimental method

X-RAY DIFFRACTION (1.9 Å)