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1JTQ

E. coli TS Complex with dUMP and the Pyrrolo(2,3-d)pyrimidine-based Antifolate LY341770

Summary for 1JTQ
Entry DOI10.2210/pdb1jtq/pdb
Related1JTU 1JU6 1JUJ
DescriptorTHYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-4-(2H-TETRAZOL-5-YL)-BUTYRIC ACID, ... (4 entities in total)
Functional Keywordsantifolate, cancer, drug resistance, dtmp synthesis, transferase
Biological sourceEscherichia coli
Cellular locationCytoplasm : P0A884
Total number of polymer chains2
Total formula weight62638.57
Authors
Sayre, P.H.,Finer-Moore, J.S.,Fritz, T.A.,Biermann, D.,Gates, S.B.,MacKellar, W.C.,Patel, V.F.,Stroud, R.M. (deposition date: 2001-08-21, release date: 2001-09-19, Last modification date: 2023-08-16)
Primary citationSayre, P.H.,Finer-Moore, J.S.,Fritz, T.A.,Biermann, D.,Gates, S.B.,MacKellar, W.C.,Patel, V.F.,Stroud, R.M.
Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
J.Mol.Biol., 313:813-829, 2001
Cited by
PubMed: 11697906
DOI: 10.1006/jmbi.2001.5074
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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