1JQ7

HCMV protease dimer-interface mutant, S225Y complexed to Inhibitor BILC 408

1JQ7 の概要

• エントリーDOI: 10.2210/pdb1jq7/pdb
• 関連するPDBエントリー: 1JQ6 1WPO 2WPO
• 関連するBIRD辞書のPRD_ID: PRD_000283
• 分子名称: ASSEMBLIN, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide (2 entities in total)
• 機能のキーワード: herpesvirus, cytomegalovirus, serine protease, dimerization, enzyme activity regulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human herpesvirus 5 (Human cytomegalovirus)
• 細胞内の位置: Protease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57849.16

構造登録者

Batra, R.,Khayat, R.,Tong, L. (登録日: 2001-08-03, 公開日: 2001-09-12, 最終更新日: 2024-03-13)

• 主引用文献: Batra, R.,Khayat, R.,Tong, L.; Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease.; Nat.Struct.Biol., 8:810-817, 2001; PubMed: 11524687; DOI: 10.1038/nsb0901-810

実験手法

X-RAY DIFFRACTION (3 Å)