1JPY

Crystal structure of IL-17F

1JPY の概要

• エントリーDOI: 10.2210/pdb1jpy/pdb
• 分子名称: interleukin 17F, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: cystine-knot, cytokine, t-cell derived, dimer, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62729.58

構造登録者

Hymowitz, S.G.,Filvaroff, E.H.,Yin, J.,Lee, J.,Cai, L.,Risser, P.,Maruoka, M.,Mao, W.,Foster, J.,Kelley, R.,Pan, G.,Gurney, A.L.,de Vos, A.M.,Starovasnik, M.A. (登録日: 2001-08-03, 公開日: 2001-09-28, 最終更新日: 2024-10-30)

主引用文献

Hymowitz, S.G.,Filvaroff, E.H.,Yin, J.P.,Lee, J.,Cai, L.,Risser, P.,Maruoka, M.,Mao, W.,Foster, J.,Kelley, R.F.,Pan, G.,Gurney, A.L.,de Vos, A.M.,Starovasnik, M.A.
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
EMBO J., 20:5332-5341, 2001

PubMed Abstract: The proinflammatory cytokine interleukin 17 (IL-17) is the founding member of a family of secreted proteins that elicit potent cellular responses. We report a novel human IL-17 homolog, IL-17F, and show that it is expressed by activated T cells, can stimulate production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Unexpectedly, the crystal structure of IL-17F reveals that IL-17 family members adopt a monomer fold typical of cystine knot growth factors, despite lacking the disulfide responsible for defining the canonical "knot" structure. IL-17F dimerizes in a parallel manner like neurotrophins, and features an unusually large cavity on its surface. Remarkably, this cavity is located in precisely the same position where nerve growth factor binds its high affinity receptor, TrkA, suggesting further parallels between IL-17s and neurotrophins with respect to receptor recognition.

PubMed: 11574464
DOI: 10.1093/emboj/20.19.5332

実験手法

X-RAY DIFFRACTION (2.85 Å)