1JPS

Crystal structure of tissue factor in complex with humanized Fab D3h44

1JPS の概要

• エントリーDOI: 10.2210/pdb1jps/pdb
• 関連するPDBエントリー: 1JPT 2HFT
• 分子名称: immunoglobulin Fab D3H44, light chain, immunoglobulin Fab D3H44, heavy chain, tissue factor, ... (4 entities in total)
• 機能のキーワード: antigen-antibody recognition, humanized antibody, blood coagulation, interface water molecules, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 72393.42

構造登録者

Faelber, K.,Kirchhofer, D.,Presta, L.,Kelley, R.F.,Muller, Y.A. (登録日: 2001-08-03, 公開日: 2002-02-03, 最終更新日: 2023-10-25)

• 主引用文献: Faelber, K.,Kirchhofer, D.,Presta, L.,Kelley, R.F.,Muller, Y.A.; The 1.85 A resolution crystal structures of tissue factor in complex with humanized Fab D3h44 and of free humanized Fab D3h44: revisiting the solvation of antigen combining sites.; J.Mol.Biol., 313:83-97, 2001; PubMed: 11601848; DOI: 10.1006/jmbi.2001.5036

実験手法

X-RAY DIFFRACTION (1.85 Å)