1JMW

Propagating Conformational Changes Over Long (And Short) Distances

Summary for 1JMW

• Entry DOI: 10.2210/pdb1jmw/pdb
• Descriptor: methyl-accepting chemotaxis protein II (2 entities in total)
• Functional Keywords: chemotaxis, bacterial chemotactic receptor, signaling protein
• Biological source: Salmonella typhimurium
• Cellular location: Cell inner membrane; Multi-pass membrane protein: P02941
• Total number of polymer chains: 1
• Total formula weight: 16350.23

Authors

Koshland Jr., D.E.,Yu, E.W. (deposition date: 2001-07-20, release date: 2001-08-15, Last modification date: 2024-02-07)

Primary citation

Yu, E.W.,Koshland Jr., D.E.
Propagating conformational changes over long (and short) distances in proteins.
Proc.Natl.Acad.Sci.USA, 98:9517-9520, 2001

PubMed Abstract: The problem of the propagation of conformational changes over long distances or through a closely packed protein is shown to fit a model of a ligand-induced conformational change between two protein states selected by evolution. Moreover, the kinetics of the pathway between these states is also selected so that the energy of ligand binding and the speed of the transition between conformational states are physiologically appropriate. The crystallographic data of a wild-type aspartate receptor that has negative cooperativity and a mutant that has no cooperativity but has native transmembrane signaling are shown to support this model.

PubMed: 11504940
DOI: 10.1073/pnas.161239298

Experimental method

X-RAY DIFFRACTION (1.9 Å)