1JK3

Crystal structure of human MMP-12 (Macrophage Elastase) at true atomic resolution

Summary for 1JK3

Entry DOI	10.2210/pdb1jk3/pdb
Descriptor	MACROPHAGE METALLOELASTASE, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	matrix metalloproteinase, batimastat, bb94, hydroxamic acid, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	1
Total formula weight	18187.22
Authors	Lang, R.,Kocourek, A.,Braun, M.,Tschesche, H.,Huber, R.,Bode, W.,Maskos, K. (deposition date: 2001-07-11, release date: 2001-09-28, Last modification date: 2023-08-16)
Primary citation	Lang, R.,Kocourek, A.,Braun, M.,Tschesche, H.,Huber, R.,Bode, W.,Maskos, K. Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure. J.Mol.Biol., 312:731-742, 2001 Cited by PubMed: 11575928 DOI: 10.1006/jmbi.2001.4954 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.09 Å)

Structure validation