1JK3
Crystal structure of human MMP-12 (Macrophage Elastase) at true atomic resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | MACROPHAGE METALLOELASTASE | polymer | 158 | 17458.5 | 1 | UniProt (P39900) Pfam (PF00413) In PDB | Homo sapiens (human) | MMP-12; HME; MATRIX METALLOPROTEINASE-12; MMP-12; metalloelastase HME |
| 2 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | A | 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE | non-polymer | 477.6 | 1 | Chemie (BAT) | |||
| 5 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 106 - 263 (UniProt: P39900)
| PDB | External Database | Details |
|---|---|---|
| Ala 219 | Glu 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17458.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 728.7 | |
| All* | Total formula weight | 18187.2 |
