1JH1

Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor

Summary for 1JH1

Entry DOI	10.2210/pdb1jh1/pdb
Descriptor	Matrix Metalloproteinase 8, CALCIUM ION, ZINC ION, ... (5 entities in total)
Functional Keywords	collagenase, inhibitor, thiadiazine, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasmic granule: P22894
Total number of polymer chains	1
Total formula weight	18102.88
Authors	Schroder, J.,Henke, A.,Wenzel, H.,Brandstetter, H.,Stammler, H.G.,Stammler, A.,Pfeiffer, W.D.,Tschesche, H. (deposition date: 2001-06-27, release date: 2001-12-27, Last modification date: 2024-04-03)
Primary citation	Schroder, J.,Henke, A.,Wenzel, H.,Brandstetter, H.,Stammler, H.G.,Stammler, A.,Pfeiffer, W.D.,Tschesche, H. Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. J.Med.Chem., 44:3231-3243, 2001 Cited by PubMed: 11563922 DOI: 10.1021/jm010887p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation