1JG5
CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP
Summary for 1JG5
| Entry DOI | 10.2210/pdb1jg5/pdb |
| Descriptor | GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, POTASSIUM ION (3 entities in total) |
| Functional Keywords | alpha/beta structure, beta sheet, protein binding |
| Biological source | Rattus norvegicus (Norway rat) |
| Cellular location | Nucleus (By similarity): P70552 |
| Total number of polymer chains | 5 |
| Total formula weight | 47955.64 |
| Authors | Bader, G.,Schiffmann, S.,Herrmann, A.,Fischer, M.,Gutlich, M.,Auerbach, G.,Ploom, T.,Bacher, A.,Huber, R.,Lemm, T. (deposition date: 2001-06-23, release date: 2001-10-10, Last modification date: 2024-03-13) |
| Primary citation | Bader, G.,Schiffmann, S.,Herrmann, A.,Fischer, M.,Gutlich, M.,Auerbach, G.,Ploom, T.,Bacher, A.,Huber, R.,Lemm, T. Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP. J.Mol.Biol., 312:1051-1057, 2001 Cited by PubMed Abstract: Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP). The 2.6 A resolution crystal structure of rat GFRP shows that the protein forms a pentamer. This indicates a model for the interaction of mammalian GTP cyclohydrolase I with its regulator, GFRP. Kinetic investigations of human GTP cyclohydrolase I in complex with rat and human GFRP showed similar regulatory effects of both GFRP proteins. PubMed: 11580249DOI: 10.1006/jmbi.2001.5011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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