1JF7
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836
Summary for 1JF7
Entry DOI | 10.2210/pdb1jf7/pdb |
Related | 1G7F 1G7G |
Descriptor | PROTEIN-TYROSINE PHOSPHATASE 1B, 5-(2-{2-[(TERT-BUTOXY-HYDROXY-METHYL)-AMINO]-1-HYDROXY-3-PHENYL-PROPYLAMINO}-3-HYDROXY-3-PENTYLAMINO-PROPYL)-2-CARBOXYMETHOXY-BENZOIC ACID (3 entities in total) |
Functional Keywords | hydrolase (phosphorylation), tyrosine phosphatase, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 2 |
Total formula weight | 70046.85 |
Authors | Larsen, S.D.,Barf, T.,Liljebris, C.,May, P.D.,Ogg, D.,O'Sullivan, T.J.,Palazuk, B.J.,Schostarez, H.J.,Stevens, F.C.,Bleasdale, J.E. (deposition date: 2001-06-20, release date: 2002-02-13, Last modification date: 2023-08-16) |
Primary citation | Larsen, S.D.,Barf, T.,Liljebris, C.,May, P.D.,Ogg, D.,O'Sullivan, T.J.,Palazuk, B.J.,Schostarez, H.J.,Stevens, F.C.,Bleasdale, J.E. Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B. J.Med.Chem., 45:598-622, 2002 Cited by PubMed: 11806712DOI: 10.1021/jm010393s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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