1G7F

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177496

Summary for 1G7F

• Entry DOI: 10.2210/pdb1g7f/pdb
• Related: 1G7G
• Descriptor: PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, 2-{4-[(2S)-2-[({[(1S)-1-CARBOXY-2-PHENYLETHYL]AMINO}CARBONYL)AMINO]-3-OXO-3-(PENTYLAMINO)PROPYL]PHENOXY}MALONIC ACID (3 entities in total)
• Functional Keywords: hydrolase (phosphorylation), tyrosine phosphatase, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• Total number of polymer chains: 1
• Total formula weight: 35250.10

Authors

Bleasdale, J.E.,Ogg, D.,Larsen, S.D. (deposition date: 2000-11-10, release date: 2001-06-06, Last modification date: 2023-08-09)

• Primary citation: Bleasdale, J.E.,Ogg, D.,Palazuk, B.J.,Jacob, C.S.,Swanson, M.L.,Wang, X.Y.,Thompson, D.P.,Conradi, R.A.,Mathews, W.R.,Laborde, A.L.,Stuchly, C.W.,Heijbel, A.,Bergdahl, K.,Bannow, C.A.,Smith, C.W.,Svensson, C.,Liljebris, C.,Schostarez, H.J.,May, P.D.,Stevens, F.C.,Larsen, S.D.; Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.; Biochemistry, 40:5642-5654, 2001; PubMed: 11341829; DOI: 10.1021/bi002865v

Experimental method

X-RAY DIFFRACTION (1.8 Å)