1JF7

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836

1JF7 の概要

• エントリーDOI: 10.2210/pdb1jf7/pdb
• 関連するPDBエントリー: 1G7F 1G7G
• 分子名称: PROTEIN-TYROSINE PHOSPHATASE 1B, 5-(2-{2-[(TERT-BUTOXY-HYDROXY-METHYL)-AMINO]-1-HYDROXY-3-PHENYL-PROPYLAMINO}-3-HYDROXY-3-PENTYLAMINO-PROPYL)-2-CARBOXYMETHOXY-BENZOIC ACID (3 entities in total)
• 機能のキーワード: hydrolase (phosphorylation), tyrosine phosphatase, inhibitor, complex, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70046.85

構造登録者

Larsen, S.D.,Barf, T.,Liljebris, C.,May, P.D.,Ogg, D.,O'Sullivan, T.J.,Palazuk, B.J.,Schostarez, H.J.,Stevens, F.C.,Bleasdale, J.E. (登録日: 2001-06-20, 公開日: 2002-02-13, 最終更新日: 2023-08-16)

• 主引用文献: Larsen, S.D.,Barf, T.,Liljebris, C.,May, P.D.,Ogg, D.,O'Sullivan, T.J.,Palazuk, B.J.,Schostarez, H.J.,Stevens, F.C.,Bleasdale, J.E.; Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.; J.Med.Chem., 45:598-622, 2002; PubMed: 11806712; DOI: 10.1021/jm010393s

実験手法

X-RAY DIFFRACTION (2.2 Å)