1JDG

Solution Structure of a Trans-Opened (10S)-dA Adduct of (+)-(7S,8R,9S,10R)-7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully Complementary DNA Duplex

Summary for 1JDG

• Entry DOI: 10.2210/pdb1jdg/pdb
• Descriptor: 5'-D(*CP*GP*GP*TP*CP*(BPA)AP*CP*GP*AP*GP*G)-3', 5'-D(*CP*CP*TP*CP*GP*TP*GP*AP*CP*CP*G)-3', 7S,8R,9R-TRIHYDROXY-7,8,9,10-TETRAHYDRO BENZO[A]PYRENE (3 entities in total)
• Functional Keywords: syn glycosidic torsion angle, benzo[a]pyrene diol epoxide, da adduct, dna
• Total number of polymer chains: 2
• Total formula weight: 7013.72

Authors

Pradhan, P.,Tirumala, S.,Liu, X.,Sayer, J.M.,Jerina, D.M.,Yeh, H.J.C. (deposition date: 2001-06-13, release date: 2001-07-04, Last modification date: 2022-02-23)

• Primary citation: Pradhan, P.,Tirumala, S.,Liu, X.,Sayer, J.M.,Jerina, D.M.,Yeh, H.J.; Solution structure of a trans-opened (10S)-dA adduct of (+)-(7S,8R,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a fully complementary DNA duplex: evidence for a major syn conformation.; Biochemistry, 40:5870-5881, 2001; PubMed: 11352722; DOI: 10.1021/bi002896q

Experimental method

SOLUTION NMR