1JCR

CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE

1JCR の概要

• エントリーDOI: 10.2210/pdb1jcr/pdb
• 関連するPDBエントリー: 1D8D 1FT1 1JCQ 1JCS
• 分子名称: PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT, SYNTHETIC TETRAPEPTIDE CVFM, ... (7 entities in total)
• 機能のキーワード: ftase, pft, pftase, ft, fpt, farnesyltransferase, farnesyl transferase, farnesyl protein transferase, caax, ras, cancer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 93886.92

構造登録者

Long, S.B.,Casey, P.J.,Beese, L.S. (登録日: 2001-06-11, 公開日: 2001-11-02, 最終更新日: 2023-08-16)

• 主引用文献: Long, S.B.,Hancock, P.J.,Kral, A.M.,Hellinga, H.W.,Beese, L.S.; The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.; Proc.Natl.Acad.Sci.USA, 98:12948-12953, 2001; PubMed: 11687658; DOI: 10.1073/pnas.241407898

実験手法

X-RAY DIFFRACTION (2 Å)