1J46

3D Solution NMR Structure of the Wild Type HMG-BOX Domain of the Human Male Sex Determining Factor Sry Complexed to DNA

Summary for 1J46

• Entry DOI: 10.2210/pdb1j46/pdb
• Related: 1J47
• Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*CP*AP*AP*AP*CP*AP*CP*C)-3', 5'-D(*GP*GP*TP*GP*TP*TP*TP*GP*TP*GP*CP*AP*GP*G)-3', SEX-DETERMINING REGION Y PROTEIN (3 entities in total)
• Functional Keywords: male sex determining factor, sry, sex-reversal mutation, dna bending mutant, dipolar couplings, multidimensional nmr, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus speckle: Q05066
• Total number of polymer chains: 3
• Total formula weight: 19216.15

Authors

Clore, G.M.,Murphy, E.C. (deposition date: 2001-07-23, release date: 2001-10-03, Last modification date: 2023-12-27)

• Primary citation: Murphy, E.C.,Zhurkin, V.B.,Louis, J.M.,Cornilescu, G.,Clore, G.M.; Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation.; J.Mol.Biol., 312:481-499, 2001; PubMed: 11563911; DOI: 10.1006/jmbi.2001.4977

Experimental method

SOLUTION NMR