1J1A
PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIa) WITH ANTI-INFLAMMATORY ACTIVITY
Summary for 1J1A
Entry DOI | 10.2210/pdb1j1a/pdb |
Descriptor | Phospholipase A2, CALCIUM ION, (S)-5-(4-BENZYLOXY-PHENYL)-4-(7-PHENYL-HEPTANOYLAMINO)-PENTANOIC ACID, ... (4 entities in total) |
Functional Keywords | medicinal chemistry, enzyme inhibitor, structure-activity relationships, inflammation, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Peripheral membrane protein: P14555 |
Total number of polymer chains | 2 |
Total formula weight | 29025.60 |
Authors | Hansford, K.A.,Reid, R.C.,Clark, C.I.,Tyndall, J.D.A.,Whitehouse, M.W.,Guthrie, T.,McGeary, R.P.,Schafer, K.,Martin, J.L.,Fairlie, D.P. (deposition date: 2002-12-03, release date: 2003-03-18, Last modification date: 2023-10-25) |
Primary citation | Hansford, K.A.,Reid, R.C.,Clark, C.I.,Tyndall, J.D.A.,Whitehouse, M.W.,Guthrie, T.,McGeary, R.P.,Schafer, K.,Martin, J.L.,Fairlie, D.P. D-Tyrosine as a Chiral Precusor to Potent Inhibitors of Human Nonpancreatic Secretory Phospholipase A2 (IIa) with Antiinflammatory Activity Chembiochem, 4:181-185, 2003 Cited by PubMed: 12616631DOI: 10.1002/cbic.200390029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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