Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro

Summary for 1J04

Descriptoralanine--glyoxylate aminotransferase, (AMINOOXY)ACETIC ACID, GLYCEROL, ... (4 entities in total)
Functional Keywordstransferase, aminotransferase, pyridoxal phosphate
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight44126.82
Zhang, X.,Djordjevic, S.,Bartlam, M.,Ye, S.,Rao, Z.,Danpure, C.J. (deposition date: 2002-10-30, release date: 2003-11-11, Last modification date: 2018-07-25)
Primary citation
Djordjevic, S.,Zhang, X.,Bartlam, M.,Ye, S.,Rao, Z.,Danpure, C.J.
Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting.
Acta Crystallogr.,Sect.F, 66:233-236, 2010
PubMed: 20208150 (PDB entries with the same primary citation)
DOI: 10.1107/S1744309109054645
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.273181.3%4.7%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload