Crystal Structure of CPA and sulfamide-based inhibitor complex

Summary for 1IY7

DescriptorCarboxypeptidase A, ZINC ION, PHENYLALANINE-N-SULFONAMIDE, ... (4 entities in total)
Functional Keywordsprotein-inhibitor complex, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space P00730
Total number of polymer chains1
Total molecular weight34752.14
Kim, S.J.,Woo, J.R.,Park, J.D.,Kim, D.H.,Ryu, S.E. (deposition date: 2002-07-24, release date: 2003-01-28, Last modification date: 2011-07-13)
Primary citation
Park, J.D.,Kim, D.H.,Kim, S.J.,Woo, J.R.,Ryu, S.E.
Sulfamide-Based Inhibitors for Carboxypeptidase A. Novel Type Transition State Analogue Inhibitors for Zinc Proteases
J.Med.Chem., 45:5295-5302, 2002
PubMed: 12431056 (PDB entries with the same primary citation)
DOI: 10.1021/jm020258v
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20870.3%2.7%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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