1IV6

Solution Structure of the DNA Complex of Human TRF1

Summary for 1IV6

• Entry DOI: 10.2210/pdb1iv6/pdb
• Related: 1ity
• NMR Information: BMRB: 5361
• Descriptor: 5'-D(*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3', 5'-D(*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*C)-3', TELOMERIC REPEAT BINDING FACTOR 1 (3 entities in total)
• Functional Keywords: telomeres, protein-dna complex, myb domain, helix-turn-helix, riken structural genomics/proteomics initiative, rsgi, structural genomics, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P54274
• Total number of polymer chains: 3
• Total formula weight: 16542.14

Authors

Nishikawa, T.,Okamura, H.,Nagadoi, A.,Konig, P.,Rhodes, D.,Nishimura, Y.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2002-03-14, release date: 2002-04-17, Last modification date: 2023-12-27)

Primary citation

Nishikawa, T.,Okamura, H.,Nagadoi, A.,Konig, P.,Rhodes, D.,Nishimura, Y.
Solution structure of a telomeric DNA complex of human TRF1.
Structure, 9:1237-1251, 2001

PubMed Abstract: Mammalian telomeres consist of long tandem arrays of double-stranded TTAGGG sequence motif packaged by TRF1 and TRF2. In contrast to the DNA binding domain of c-Myb, which consists of three imperfect tandem repeats, DNA binding domains of both TRF1 and TRF2 contain only a single Myb repeat. In a DNA complex of c-Myb, both the second and third repeats are closely packed in the major groove of DNA and recognize a specific base sequence cooperatively.

PubMed: 11738049
DOI: 10.1016/S0969-2126(01)00688-8

Experimental method

SOLUTION NMR