1IRA

COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA)

Summary for 1IRA

Entry DOI	10.2210/pdb1ira/pdb
Descriptor	INTERLEUKIN-1 RECEPTOR ANTAGONIST, INTERLEUKIN-1 RECEPTOR, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	cytokine receptor, receptor antagonist, immunoglobulin fold, complex (cytokine receptor-antagonist), complex (cytokine receptor-antagonist) complex, complex (cytokine receptor/antagonist)
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: P18510 Membrane ; Single-pass type I membrane protein : P14778
Total number of polymer chains	2
Total formula weight	54771.97
Authors	Schreuder, H.A.,Tardif, C.,Tramp-Kalmeyer, S.,Soffientini, A.,Sarubbi, E.,Akeson, A.,Bowlin, T.,Yanofsky, S.,Barrett, R.W. (deposition date: 1998-04-09, release date: 1998-06-17, Last modification date: 2023-08-09)
Primary citation	Schreuder, H.,Tardif, C.,Trump-Kallmeyer, S.,Soffientini, A.,Sarubbi, E.,Akeson, A.,Bowlin, T.,Yanofsky, S.,Barrett, R.W. A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. Nature, 386:194-200, 1997 Cited by PubMed: 9062194 DOI: 10.1038/386194a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation