1INX

A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES

Summary for 1INX

• Entry DOI: 10.2210/pdb1inx/pdb
• Descriptor: INFLUENZA A SUBTYPE N2 NEURAMINIDASE, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: hydrolase, o-glycosyl, neuraminidase, sialidase
• Biological source: Influenza A virus
• Cellular location: Virion membrane (By similarity): P06820
• Total number of polymer chains: 1
• Total formula weight: 45084.78

Authors

White, C.L.,Janakiraman, M.N.,Laver, W.G.,Philippon, C.,Vasella, A.,Air, G.M.,Luo, M. (deposition date: 1994-09-26, release date: 1995-02-07, Last modification date: 2020-07-29)

• Primary citation: White, C.L.,Janakiraman, M.N.,Laver, W.G.,Philippon, C.,Vasella, A.,Air, G.M.,Luo, M.; A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.; J.Mol.Biol., 245:623-634, 1995; PubMed: 7844831; DOI: 10.1006/jmbi.1994.0051

Experimental method

X-RAY DIFFRACTION (2.4 Å)