1INX

A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES

Experimental procedure

Spacegroup name	C 2 2 21
Unit cell lengths	120.420, 139.830, 140.070
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	8.000 - 2.400
R-factor	0.179
Rwork	0.179
RMSD bond length	0.013
RMSD bond angle	1.940 *
Phasing software	X-PLOR
Refinement software	X-PLOR

Data quality characteristics

	Overall
Low resolution limit [Å]	9999.000 *
High resolution limit [Å]	2.380 *
Rmerge	0.080 *
Number of reflections	35409
Completeness [%]	74.1
Redundancy	1.87 *

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	Vapor diffusion, hanging drop *	7.2 *		NATIVE CRYSTALS SOAKED IN 10MM EPANA SOLUTION, PH 7.2.

Crystallization Reagents in Literatures

ID	crystal ID	solution	reagent name	concentration (unit)	details
1	1	reservoir	phosphate	0.1 (M)
2	1	reservoir		0.15 (M)
3	1	reservoir	PEG3350	12.5 (%(w/v))