1INR

CYTOKINE SYNTHESIS

1INR の概要

• エントリーDOI: 10.2210/pdb1inr/pdb
• 分子名称: INTERLEUKIN-10 (2 entities in total)
• 機能のキーワード: cytokine
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P22301
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18672.45

構造登録者

Walter, M.R. (登録日: 1995-07-31, 公開日: 1996-10-14, 最終更新日: 2024-10-30)

主引用文献

Walter, M.R.,Nagabhushan, T.L.
Crystal structure of interleukin 10 reveals an interferon gamma-like fold.
Biochemistry, 34:12118-12125, 1995

PubMed Abstract: The crystal structure of recombinant human interleukin 10 (rhIL-10) has been determined by X-ray crystallography at 2.0 A resolution. Interleukin 10 is a dimer composed of identical polypeptide chains related by a 2-fold axis. The molecule is predominantly alpha-helical. The main-chain fold resembles that of interferon gamma (IFN-gamma) in which the structural integrity of each domain is dependent on the intertwining of helices from each peptide chain. Comparison of rhIL-10 and IFN-gamma reveals differences in helix lengths and orientations of the 2-fold related domains. Interleukin 10 and IFN-gamma contain several conserved residues in their internal cores which suggest a possible "fingerprint" for detection of other members of this fold.

PubMed: 7547951
DOI: 10.1021/bi00038a004

実験手法

X-RAY DIFFRACTION (2 Å)