1ILK

INTERLEUKIN-10 CRYSTAL STRUCTURE REVEALS THE FUNCTIONAL DIMER WITH AN UNEXPECTED TOPOLOGICAL SIMILARITY TO INTERFERON GAMMA

Summary for 1ILK

• Entry DOI: 10.2210/pdb1ilk/pdb
• Descriptor: INTERLEUKIN-10 (2 entities in total)
• Functional Keywords: cytokine
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P22301
• Total number of polymer chains: 1
• Total formula weight: 17800.60

Authors

Zdanov, A.,Schalk-Hihi, C.,Gustchina, A.,Wlodawer, A. (deposition date: 1995-04-21, release date: 1995-07-10, Last modification date: 2024-10-16)

Primary citation

Zdanov, A.,Schalk-Hihi, C.,Gustchina, A.,Tsang, M.,Weatherbee, J.,Wlodawer, A.
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.
Structure, 3:591-601, 1995

PubMed Abstract: Interleukin (IL)-10 is a cytokine that inhibits production of other regulatory factors, including interferon gamma (IFN-gamma) and IL-2. A dimer of IL-10 is present in solution and is presumed to participate in receptor binding, but the nature of the dimer has not been previously reported. An atomic model is necessary to interpret biological activity of IL-10 and to design mutants with agonistic or antagonistic properties.

PubMed: 8590020
DOI: 10.1016/S0969-2126(01)00193-9

Experimental method

X-RAY DIFFRACTION (1.8 Å)