1ILK

INTERLEUKIN-10 CRYSTAL STRUCTURE REVEALS THE FUNCTIONAL DIMER WITH AN UNEXPECTED TOPOLOGICAL SIMILARITY TO INTERFERON GAMMA

1ILK の概要

• エントリーDOI: 10.2210/pdb1ilk/pdb
• 分子名称: INTERLEUKIN-10 (2 entities in total)
• 機能のキーワード: cytokine
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P22301
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17800.60

構造登録者

Zdanov, A.,Schalk-Hihi, C.,Gustchina, A.,Wlodawer, A. (登録日: 1995-04-21, 公開日: 1995-07-10, 最終更新日: 2024-10-16)

主引用文献

Zdanov, A.,Schalk-Hihi, C.,Gustchina, A.,Tsang, M.,Weatherbee, J.,Wlodawer, A.
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.
Structure, 3:591-601, 1995

PubMed Abstract: Interleukin (IL)-10 is a cytokine that inhibits production of other regulatory factors, including interferon gamma (IFN-gamma) and IL-2. A dimer of IL-10 is present in solution and is presumed to participate in receptor binding, but the nature of the dimer has not been previously reported. An atomic model is necessary to interpret biological activity of IL-10 and to design mutants with agonistic or antagonistic properties.

PubMed: 8590020
DOI: 10.1016/S0969-2126(01)00193-9

実験手法

X-RAY DIFFRACTION (1.8 Å)