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1ILH

Crystal Structure of Human Pregnane X Receptor Ligand Binding Domain Bound to SR12813

Summary for 1ILH
Entry DOI10.2210/pdb1ilh/pdb
Related1ILG
DescriptorORPHAN NUCLEAR RECEPTOR PXR, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER (3 entities in total)
Functional Keywordsnuclear receptor, multiple binding modes, xenobiotic, promiscuous, ligand, gene regulation
Biological sourceHomo sapiens (human)
Cellular locationNucleus : O75469
Total number of polymer chains1
Total formula weight36785.40
Authors
Watkins, R.E.,Redinbo, M.R. (deposition date: 2001-05-08, release date: 2001-06-27, Last modification date: 2023-08-16)
Primary citationWatkins, R.E.,Wisely, G.B.,Moore, L.B.,Collins, J.L.,Lambert, M.H.,Williams, S.P.,Willson, T.M.,Kliewer, S.A.,Redinbo, M.R.
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
Science, 292:2329-2333, 2001
Cited by
PubMed: 11408620
DOI: 10.1126/science.1060762
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.76 Å)
Structure validation

217705

건을2024-03-27부터공개중

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