1IJR

Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic

1IJR の概要

• エントリーDOI: 10.2210/pdb1ijr/pdb
• 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK, (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID (2 entities in total)
• 機能のキーワード: tyrosine-protein kinase, transferase-signaling protein complex, transferase/signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P06239
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12449.84

構造登録者

Kawahata, N.H.,Yang, M.H.,Luke, G.P.,Shakespeare, W.C.,Sundaramoorthi, R. (登録日: 2001-04-27, 公開日: 2002-05-01, 最終更新日: 2024-02-07)

• 主引用文献: Kawahata, N.,Yang, M.G.,Luke, G.P.,Shakespeare, W.C.,Sundaramoorthi, R.,Wang, Y.,Johnson, D.,Merry, T.,Violette, S.,Guan, W.,Bartlett, C.,Smith, J.,Hatada, M.,Lu, X.,Dalgarno, D.C.,Eyermann, C.J.,Bohacek, R.S.,Sawyer, T.K.; A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.; Bioorg.Med.Chem.Lett., 11:2319-2323, 2001; PubMed: 11527723; DOI: 10.1016/S0960-894X(01)00446-2

実験手法

X-RAY DIFFRACTION (2.2 Å)