1IIY

Solution NMR Structure of Complex of 1:2 Cyanovirin-N:Man-Alpha1,2-Man-Alpha Restrained Regularized Mean Coordinates

1IIY の概要

• エントリーDOI: 10.2210/pdb1iiy/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900111
• 分子名称: CYANOVIRIN-N, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose (2 entities in total)
• 機能のキーワード: hiv-inactivating protein, man-alpha1, 2-man-alpha, antiviral protein
• 由来する生物種: Nostoc ellipsosporum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11706.68

構造登録者

Bewley, C.A. (登録日: 2001-04-24, 公開日: 2001-10-24, 最終更新日: 2024-11-13)

主引用文献

Bewley, C.A.
Solution Structure of a Cyanovirin-N:Man alpha 1-2Man alpha Complex. Structural Basis for High Affinity Carbohydrate-Mediated Binding to gp120
Structure, 9:931-940, 2001

PubMed Abstract: Cyanovirin-N (CVN) is a novel, 11 kDa cyanobacterial protein that potently inhibits viral entry by diverse strains of HIV through high-affinity carbohydrate-mediated interactions with the viral envelope glycoprotein gp120. CVN contains two symmetry-related carbohydrate binding sites of differing affinities that selectively bind to Man(8) D1D3 and Man(9) with nanomolar affinities, the carbohydrates that also mediate CVN:gp120 binding. High-resolution structural studies of CVN in complex with a representative oligosaccharide are desirable for understanding the structural basis for this unprecedented specificity.

PubMed: 11591348
DOI: 10.1016/S0969-2126(01)00653-0

実験手法

SOLUTION NMR