1IIP

Bovine Cyclophilin 40, Tetragonal Form

1IIP の概要

• エントリーDOI: 10.2210/pdb1iip/pdb
• 関連するPDBエントリー: 1IHG
• 分子名称: Cyclophilin 40, GLYCEROL (3 entities in total)
• 機能のキーワード: ppiase immunophilin tetratricopeptide, isomerase
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Cytoplasm: P26882
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40770.41

構造登録者

Taylor, P.,Dornan, J.,Carrello, A.,Minchin, R.F.,Ratajczak, T.,Walkinshaw, M.D. (登録日: 2001-04-24, 公開日: 2001-05-16, 最終更新日: 2024-11-06)

主引用文献

Taylor, P.,Dornan, J.,Carrello, A.,Minchin, R.F.,Ratajczak, T.,Walkinshaw, M.D.
Two structures of cyclophilin 40: folding and fidelity in the TPR domains.
Structure, 9:431-438, 2001

PubMed Abstract: The "large immunophilin" family consists of domains of cyclophilin or FK506 binding protein linked to a tetratricopeptide (TPR) domain. They are intimately associated with steroid receptor complexes and bind to the C-terminal domain of Hsp90 via the TPR domain. The competitive binding of specific large immunophilins and other TPR-Hsp90 proteins provides a regulatory mechanism for Hsp90 chaperone activity.

PubMed: 11377203
DOI: 10.1016/S0969-2126(01)00603-7

実験手法

X-RAY DIFFRACTION (2 Å)