1IC8

HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT

Summary for 1IC8

• Entry DOI: 10.2210/pdb1ic8/pdb
• Related: 1AU7 1LFB 1OCT 2LFB
• Descriptor: 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3', HEPATOCYTE NUCLEAR FACTOR 1-ALPHA, ... (4 entities in total)
• Functional Keywords: transcription regulation; dna-binding; pou domain; diabetes; disease mutation; mody3, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P20823
• Total number of polymer chains: 4
• Total formula weight: 57857.03

Authors

Chi, Y.-I.,Frantz, J.D.,Oh, B.-C.,Hansen, L.,Dhe-Paganon, S.,Shoelson, S.E. (deposition date: 2001-03-30, release date: 2002-11-27, Last modification date: 2024-02-07)

• Primary citation: Chi, Y.-I.,Frantz, J.D.,Oh, B.-C.,Hansen, L.,Dhe-Paganon, S.,Shoelson, S.E.; Diabetes mutations delineate an atypical POU domains in HNF1-Alpha; Mol.Cell, 10:1129-1137, 2002; PubMed: 12453420; DOI: 10.1016/S1097-2765(02)00704-9

Experimental method

X-RAY DIFFRACTION (2.6 Å)