1I8D

CRYSTAL STRUCTURE OF RIBOFLAVIN SYNTHASE

Summary for 1I8D

• Entry DOI: 10.2210/pdb1i8d/pdb
• Descriptor: RIBOFLAVIN SYNTHASE (2 entities in total)
• Functional Keywords: riboflavin synthase, riboflavin biosynthesis, antimicrobial target, structure-based design, escherichia coli, transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 3
• Total formula weight: 70418.65

Authors

Liao, D.-I.,Wawrzak, Z.,Calabrese, J.C.,Viitanen, P.V.,Jordan, D.B. (deposition date: 2001-03-13, release date: 2001-09-19, Last modification date: 2024-02-07)

Primary citation

Liao, D.I.,Wawrzak, Z.,Calabrese, J.C.,Viitanen, P.V.,Jordan, D.B.
Crystal structure of riboflavin synthase.
Structure, 9:399-408, 2001

PubMed Abstract: Riboflavin synthase catalyzes the dismutation of two molecules of 6,7-dimethyl-8-(1'-D-ribityl)-lumazine to yield riboflavin and 4-ribitylamino-5-amino-2,6-dihydroxypyrimidine. The homotrimer of 23 kDa subunits has no cofactor requirements for catalysis. The enzyme is nonexistent in humans and is an attractive target for antimicrobial agents of organisms whose pathogenicity depends on their ability to biosynthesize riboflavin.

PubMed: 11377200
DOI: 10.1016/S0969-2126(01)00600-1

Experimental method

X-RAY DIFFRACTION (2 Å)