1I7X

BETA-CATENIN/E-CADHERIN COMPLEX

1I7X の概要

• エントリーDOI: 10.2210/pdb1i7x/pdb
• 関連するPDBエントリー: 1G3J 1I7W 2BCT 3BCT
• 分子名称: BETA-CATENIN, EPITHELIAL-CADHERIN (3 entities in total)
• 機能のキーワード: e-cadherin, cell adhesion, beta-catenin, protein-protein complex, extended interface, armadillo repeat
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Cytoplasm: Q02248; Cell junction: P09803
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151696.28

構造登録者

Huber, A.H.,Weis, W.I. (登録日: 2001-03-10, 公開日: 2001-05-16, 最終更新日: 2023-08-09)

主引用文献

Huber, A.H.,Weis, W.I.
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.
Cell(Cambridge,Mass.), 105:391-402, 2001

PubMed Abstract: As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.

PubMed: 11348595
DOI: 10.1016/S0092-8674(01)00330-0

実験手法

X-RAY DIFFRACTION (3 Å)