1I7M

HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE

1I7M の概要

• エントリーDOI: 10.2210/pdb1i7m/pdb
• 関連するPDBエントリー: 1I72 1I79 1I7B 1I7C 1JEN
• 分子名称: S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN, 1,4-DIAMINOBUTANE, ... (5 entities in total)
• 機能のキーワード: spermidine biosynthesis, lyase, decarboxylase, pyruvate, s-adenosylmethionine, sandwich, allosteric enzyme, pyruvoyl
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 78495.39

構造登録者

Tolbert, W.D.,Ekstrom, J.L.,Mathews, I.I.,Secrist III, J.A.,Pegg, A.E.,Ealick, S.E. (登録日: 2001-03-09, 公開日: 2001-08-22, 最終更新日: 2023-11-15)

• 主引用文献: Tolbert, W.D.,Ekstrom, J.L.,Mathews, I.I.,Secrist III, J.A.,Kapoor, P.,Pegg, A.E.,Ealick, S.E.; The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.; Biochemistry, 40:9484-9494, 2001; PubMed: 11583147; DOI: 10.1021/bi010735w

実験手法

X-RAY DIFFRACTION (2.24 Å)